Accuracy and Robustness of Analyses Based on Numbers of Genes in Observed Segments
نویسندگان
چکیده
We analyze a model of the distribution of linkage disruption points (breakpoints) along the chromosome. We calculate the variance of an estimator of the number of breakpoints and use this to assess whether or not Nadeau and Taylor were simply beneficiaries of the “luck of the draw”. In addition, we analyze a possible source of error due to the availability of chromosomal assignment only rather than mapping data on humans. Finally, given evidence of frequent local rearrangements (e.g. inversions) of chromosomal segments, we suggest a method for evaluating the pertinence of comparative maps for the interchromosomal (translocational) history of a genome.
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